The Relationship Between Vitamin D Levels and Receptor Activator of Nuclear Factor Ligand in Hashimoto’s Thyroiditis
| Autor: | Hakan Yavuzer, Selver Işık, Mahir Cengiz, İbrahim Murat Bolayırlı, Alper Döventaş, Deniz Suna Erdinçler |
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| Jazyk: | English<br />Turkish |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Haseki Tıp Bülteni, Vol 55, Iss 4, Pp 261-268 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1302-0072 2147-2688 |
| DOI: | 10.4274/haseki.21931 |
| Popis: | Aim: In order to analyze the relationship of Hashimoto’s thyroiditis with vitamin D and osteoclastogenic markers, we investigated vitamin D, osteoprotegerin (OPG) and receptor activator of nuclear factor ligand (RANKL) levels in patients over 60 years with and without Hashimoto’s thyroiditis. Methods: Eighty three female patients (49 with and 34 without Hashimoto’s thyroiditis), who attended the endocrinology and geriatrics departments between May 2013 and October 2013 were included in the study. Results: There was no statistically significant difference in the levels of vitamin D, OPG and RANKL between the groups. Vitamin D was significantly correlated with OPG and RANKL in patients with Hashimoto’s thyroiditis. In addition, a significant relationship was found between OPG and RANKL levels. Of the patients with Hashimoto’s thyroiditis, 33 were autoantibody-positive and 16 were negative. Vitamin D, OPG and RANKL levels were significantly lower in antibody-positive patients than in negative subjects. Conclucion: There were no differences in vitamin D, OPG and RANKL levels between patients with and without Hashimoto’s thyroidits. Autoantibody-positive Hashimoto’s thyroiditis group had statistically significantly lower vitamin D, OPG and RANKL levels. This reverse correlation suggests that autoantibodies may have an effect on osteoclastogenesis. |
| Databáze: | Directory of Open Access Journals |
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