Stat2 stability regulation: an intersection between immunity and carcinogenesis

Autor: Cheol-Jung Lee, Hyun-Jung An, Eun Suh Cho, Han Chang Kang, Joo Young Lee, Hye Suk Lee, Yong-Yeon Cho
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1526-1536 (2020)
Druh dokumentu: article
ISSN: 1226-3613
2092-6413
DOI: 10.1038/s12276-020-00506-6
Popis: Cancer: Significance of stability of regulatory protein The activity of STAT2, a protein stimulated by molecular signalling systems to activate selected genes in ways that can lead to cancer, is regulated by factors controlling its rate of degradation. Yong-Yeon Cho and colleagues at The Catholic University of Korea in South Korea review the role of STAT2 in links between molecular signals of the immune response and the onset of cancer. They focus on the significance of factors that regulate the stability of STAT2. One key factor appears to be the molecular mechanisms controlling the degradation of STAT2 by cellular structures called proteasomes. These structures break down proteins as part of routine cell maintenance. Deeper understanding of the stimulation, action and degradation of STAT2 will assist efforts to treat the many cancers in which STAT2 activity is involved.
Databáze: Directory of Open Access Journals
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