Better haemodynamic stability under xenon anaesthesia than under isoflurane anaesthesia during partial nephrectomy – a secondary analysis of a randomised controlled trial

Autor: Patrick Schäfer, Astrid Fahlenkamp, Rolf Rossaint, Mark Coburn, Ana Kowark
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: BMC Anesthesiology, Vol 19, Iss 1, Pp 1-12 (2019)
Druh dokumentu: article
ISSN: 1471-2253
DOI: 10.1186/s12871-019-0799-2
Popis: Abstract Background Renal dysfunction following intraoperative arterial hypotension is mainly caused by an insufficient renal blood flow. It is associated with higher mortality and morbidity rates. We hypothesised that the intraoperative haemodynamics are more stable during xenon anaesthesia than during isoflurane anaesthesia in patients undergoing partial nephrectomy. Methods We performed a secondary analysis of the haemodynamic variables collected during the randomised, single-blinded, single-centre PaNeX study, which analysed the postoperative renal function in 46 patients who underwent partial nephrectomy. The patients received either xenon or isoflurane anaesthesia with 1:1 allocation ratio. We analysed the duration of the intraoperative systolic blood pressure decrease by > 40% from baseline values and the cumulative duration of a mean arterial blood pressure (MAP) of 40% did not significantly differ between the groups (P = 0.51). The periods with a systolic blood pressure decrease by 20% from baseline, MAP decrease to values
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