Multiple infantile hepatic hemangiomas leading to consumptive hypothyroidism successfully treated with propranolol: A case report

Autor: Anjali Verma, Rashika Jain, Neha Babbar, Nancy Pherlin Kharkongor
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Family Medicine and Primary Care, Vol 9, Iss 11, Pp 5759-5762 (2020)
Druh dokumentu: article
ISSN: 2249-4863
DOI: 10.4103/jfmpc.jfmpc_1074_20
Popis: Hepatic hemangioma is a commonly encountered benign vascular tumour of liver during infancy. Acquired hypothyroidism is one of the rare manifestation of this entity. We report a 4-month-old infant born to a diabetic mother who developed acquired hypothyroidism not responding to treatment due to multiple hepatic hemangiomas. The mechanism behind is increased type 3 deiodinase activity due to hemangiomas of liver, which catalyses conversion of T4 to rT3 and T3 to T2. Hemangiomas were successfully treated with propranolol which lead to its regression and ultimately resulted in euthyroidism. Hence, screening for hepatic hemangioma should be done in all cases of congenital hypothyroidism not responding to thyroxine treatment. We also propose early initiation of treatment of hemangiomas with propranolol as the first line therapy to prevent growth retardation and intellectual loss.
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje