Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic Derivatives

Autor: Wilson R. Cunha, Ademar A. da Silva Filho, Sérgio Albuquerque, Fransérgio F. dos Santos, Lizandra G. Magalhães, Milton Groppo, Ana H. Januário, Rodrigo Cassio Sola Veneziani, Valéria M. M. Gimenez, Juliana A. Peixoto, Antônio E. M. Crotti, Márcio Luis Andrade e Silva
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Molecules, Vol 16, Iss 2, Pp 1825-1833 (2011)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules16021825
Popis: The in vitro activity of the crude hydroalcoholic extract of the aerial parts of Miconia langsdorffii Cogn. was evaluated against the promastigote forms of L. amazonensis, the causative agent of cutaneous leishmaniasis in humans. The bioassay-guided fractionation of this extract led to identification of the triterpenes ursolic acid and oleanolic acid as the major compounds in the fraction that displayed the highest activity. Several ursolic acid semi-synthetic derivatives were prepared, to find out whether more active compounds could be obtained. Among these ursolic acid-derived substances, the C-28 methyl ester derivative exhibited the best antileishmanial activity.
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