Identification of consensus hairpin loop structure among the negative sense subgenomic RNAs of SARS-CoV-2

Autor:	Naveen Prakash Bokolia, Ravisekhar Gadepalli
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	SARS-CoV-2 Subgenomic RNA Secondary structure Transcriptional pausing Hairpin loop structure Science
Zdroj:	Bulletin of the National Research Centre, Vol 47, Iss 1, Pp 1-7 (2023)
Druh dokumentu:	article
ISSN:	2522-8307
DOI:	10.1186/s42269-023-01002-3
Popis:	Abstract Background SARS-CoV-2 is the causative agent of worldwide pandemic disease coronavirus disease 19. SARS-CoV-2 bears positive sense RNA genome that has organized and complex pattern of replication/transcription process including the generation of subgenomic RNAs. Transcription regulatory sequences have important role in the pausing of replication/transcription and generation of subgenomic RNAs. Results In the present bioinformatics analysis, a consensus secondary structure was identified among negative sense subgenomic RNAs of SARS-CoV-2. This consensus region is present at the adjacent of initiation codon. Conclusions This study proposed that consensus structured domain could involve in mediating the long pausing of replication/transcription complex and responsible for subgenomic RNA production.
Databáze:	Directory of Open Access Journals
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