Retinoids stored locally in the lung are required to attenuate the severity of acute lung injury in male mice

Autor: Igor O. Shmarakov, Galina A. Gusarova, Mohammad N. Islam, María Marhuenda-Muñoz, Jahar Bhattacharya, William S. Blaner
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-36475-3
Popis: Retinoids can act as transcriptional regulators to regulate cell proliferation, differentiation, and other processes. Here, the authors show that uncompromised vitamin A (retinoid) metabolism and signaling in alveolar lipofibroblasts, endothelial and epithelial cells are required to lessen the severity of an acute inflammatory challenge in adult mouse lungs.
Databáze: Directory of Open Access Journals