| Autor: |
Hyung-Joon Kwon, Go-Eun Choi, Sangryeol Ryu, Soon Jae Kwon, Sun Chang Kim, Claire Booth, Kim E. Nichols, Hun Sik Kim |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/ncomms11686 |
| Popis: |
NK cell activation requires multiple signals. Here the authors show that while NKG2D, 2B4, or DNAM-1 receptor activation is insufficient to induce cytokine production, these signals synergize by Vav-1-mediated NF-κB multiphosphorylation, and this signaling checkpoint is defective in X-linked lymphoproliferative disease. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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