| Autor: |
Huan Tao, Jiansheng Huang, Patricia G. Yancey, Valery Yermalitsky, John L. Blakemore, Youmin Zhang, Lei Ding, Irene Zagol-Ikapitte, Fei Ye, Venkataraman Amarnath, Olivier Boutaud, John A. Oates, L. Jackson Roberts, Sean S. Davies, MacRae F. Linton |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-020-17915-w |
| Popis: |
Hypercholesterolemia is associated with lipid peroxidation induced reactive dicarbonyl adducts. Here the authors show that the dicarbonyl scavenger, 2-hydroxybenzylamine(2-HOBA), decreases reactive dicarbonyl modifications of LDL and HDL, improves HDL function, reduces atherosclerosis and promotes features of stable plaques in a mouse model of hypercholestrolemia. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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