| Autor: |
Tian-yi Zhou, Yu-lu Zhou, Mei-jia Qian, Yi-zheng Fang, Song Ye, Wen-xiu Xin, Xiao-chun Yang, Hong-hai Wu |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacological Sciences, Vol 138, Iss 2, Pp 89-95 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1016/j.jphs.2018.07.013 |
| Popis: |
Tumor-associated macrophages (TAMs) has been regarded as the most prominent component in tumor microenvironment. The correlation between TAM density and poor prognosis in Hepatocellular carcinoma (HCC) patients suggests a supportive role for TAMs in tumor progression. Here we employed a co-culture system to interrogate the molecular link between Yes-Associated Protein (YAP) and TAMs chemotaxis in HCC cells. We found that YAP activation was critical for the recruitment of TAMs towards HCC cells. Furthermore, cytokine array and quantitative RT-PCR analyses showed that IL-6 secreted by YAP-activated HCC cells might induce the TAMs recruitment. Interrupting YAP function by statins, the inhibitors of hydroxymethylglutaryl-CoA reductase, could robustly suppress the chemotaxis of TAMs. Together with our findings that the expression levels ofIL-6inhumanHCC tumors were highly correlated with the prognosis of HCC patients, the current study highlight the possibility of improving HCC treatment by targeting YAP-IL-6 mediated TAMs recruitment. Keywords: Yes-Associated Protein (YAP), Interleukin-6 (IL-6), Tumor-associated macrophages (TAMs), Tumor microenvironment, Hepatocellular carcinoma |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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