The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine

Autor: Hyoung-Soo Cho, Andrea Reboldi, Jason A. Hall, Leslie J. Berg
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-08699-9
Popis: Signals mediating tissue-specific control of immune cell fate and function remain largely uncharacterized. Here the authors uncover a requirement of ITK, a kinase mediating TCR signaling, for IL-2-dependent ILC2 cell survival specifically in the intestine.
Databáze: Directory of Open Access Journals