Research progress in colitis-induced hepatic barrier dysfunction

Autor: SHU Meng-xuan, YUAN Fang-chen, ZHOU Meng-qi, TU Shi-yan, XU Yue, QIN Hong-yan
Jazyk: čínština
Rok vydání: 2022
Předmět:
Zdroj: Jichu yixue yu linchuang, Vol 42, Iss 1, Pp 149-153 (2022)
Druh dokumentu: article
ISSN: 1001-6325
DOI: 10.16352/j.issn.1001-6325.2022.01.022
Popis: Liver barrier functions as a main structure to protect the liver from exogenous harmful substances and play an important role in maintaining secretion function, regulating bile transport and intercellular information transmission. Liver barrier protein alteration and barrier dysfunction can be induced by endotoxin, inflammatory cytokines and bile acids, which may be involved in the occurrence of colitis-related liver diseases. To explore the outcomes and underlying mechanism of intestinal inflammation on liver barrier function may support the understanding of pathogenesis of colitis-related liver diseases and thus provide clues and basic information for the prevention and treatment of colitis-related liver diseases.
Databáze: Directory of Open Access Journals