| Autor: |
Obiajulu Christian Ezeigwe, Chidinma Felicia Ezennaya, Ebele Lauretta Iloanya, Chioma Henrietta Obi, Nma Helen Ifedilichukwu, Chisom Miracle Okeke |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of HerbMed Pharmacology, Vol 11, Iss 4, Pp 503-512 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2345-5004 |
| DOI: |
10.34172/jhp.2022.58 |
| Popis: |
Introduction: Anemia is a common health condition caused by a decrease in red blood cells. Some medicinal plants are used as a remedy to treat anemia. This study compares the anti-anemic properties of different doses of the aqueous extracts of Ficus capensis (AEFC) and its combination with the aqueous extract of Cnidoscolus aconitifolius (AECA) in phenylhydrazine-induced anemic rats. Methods: Anemia was induced by intraperitoneal injection of 20 mg/kg phenylhydrazine for five consecutive days. Graded doses of the extracts were given by oral gavage once a day continuously for 30 days. At the end of the treatment, blood was collected for hematological analysis. Results: The antianemic effects of AEFC and its combination with AECA were demonstrated by significant increases (P < 0.05) in the hemoglobin (HGB), packed cell volume (PCV) and red blood cell (RBC) count of the extract-treated groups compared to the anemic control group. There was a better increase in the HGB levels of a combination of 400 mg/kg AEFC + AECA (13.97 ± 2.53) compared to 400 mg/kg AEFC (12.06 ± 0.02). The PCV increased more in 400 mg/kg combination of AEFC + AECA (41.94 ± 0.37) compared to 400 mg/kg AEFC (36.31 ± 1.51). A significant (P < 0.05) increase was observed in the RBC count of a combination of 400 mg/kg AEFC + AECA (6.36±0.51) compared to 400 mg/kg AEFC (4.75 ± 0.46). Conclusion: Although AEFC improved the haematological parameters of the animals when administered alone, its combination with AECA yielded a far much better result by totally restoring the haematological parameters of the phenylhydrazine-induced anemic rats to normal. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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