Autor: |
Michael Escobar, Oriol Careta, Nora Fernández Navas, Aleksandra Bartkowska, Ludovico Andrea Alberta, Jordina Fornell, Pau Solsona, Thomas Gemming, Annett Gebert, Elena Ibáñez, Andreu Blanquer, Carme Nogués, Jordi Sort, Eva Pellicer |
Jazyk: |
angličtina |
Rok vydání: |
2023 |
Předmět: |
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Zdroj: |
Journal of Functional Biomaterials, Vol 14, Iss 2, p 94 (2023) |
Druh dokumentu: |
article |
ISSN: |
2079-4983 |
DOI: |
10.3390/jfb14020094 |
Popis: |
Commercially available titanium alloys such as Ti-6Al-4V are established in clinical use as load-bearing bone implant materials. However, concerns about the toxic effects of vanadium and aluminum have prompted the development of Al- and V-free β-Ti alloys. Herein, a new alloy composed of non-toxic elements, namely Ti-18Mo-6Nb-5Ta (wt%), has been fabricated by arc melting. The resulting single β-phase alloy shows improved mechanical properties (Young’s modulus and hardness) and similar corrosion behavior in simulated body fluid when compared with commercial Ti-6Al-4V. To increase the cell proliferation capability of the new biomaterial, the surface of Ti-18Mo-6Nb-5Ta was modified by electrodepositing calcium phosphate (CaP) ceramic layers. Coatings with a Ca/P ratio of 1.47 were obtained at pulse current densities, −jc, of 1.8–8.2 mA/cm2, followed by 48 h of NaOH post-treatment. The thickness of the coatings has been measured by scanning electron microscopy from an ion beam cut, resulting in an average thickness of about 5 μm. Finally, cytocompatibility and cell adhesion have been evaluated using the osteosarcoma cell line Saos-2, demonstrating good biocompatibility and enhanced cell proliferation on the CaP-modified Ti-18Mo-6Nb-5Ta material compared with the bare alloy, even outperforming their CaP-modified Ti-6-Al-4V counterparts. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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