Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats

Autor: Qing-Ying Chen, Guo-Guang Wang, Wei Li, Yu-Xin Jiang, Xiao-Hua Lu, Ping-Ping Zhou
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Journal of Diabetes Research, Vol 2016 (2016)
Druh dokumentu: article
ISSN: 2314-6745
2314-6753
DOI: 10.1155/2016/9726503
Popis: Diabetic ulcers are one of the most serious and costly chronic complications for diabetic patients. Hyperglycemia-induced oxidative stress may play an important role in diabetes and its complications. The aim of the study was to explore the effect of heme oxygenase-1 on wound closure in diabetic rats. Diabetic wound model was prepared by making an incision with full thickness in STZ-induced diabetic rats. Wounds from diabetic rats were treated with 10% hemin ointment for 21 days. Increase of HO-1 protein expression enhanced anti-inflammation and antioxidant in diabetic rats. Furthermore, HO-1 increased the levels of VEGF and ICAM-1 and expressions of CBS and CSE protein. In summary, HO-1 promoted the wound closure by augmenting anti-inflammation, antioxidant, and angiogenesis in diabetic rats.
Databáze: Directory of Open Access Journals
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