A nontyphoidal Salmonella serovar domestication accompanying enhanced niche adaptation

Autor: Yan Li, Lin Teng, Xuebin Xu, Xiaomeng Li, Xianqi Peng, Xiao Zhou, Jiaxin Du, Yanting Tang, Zhijie Jiang, Zining Wang, Chenghao Jia, Anja Müller, Corinna Kehrenberg, Haoqiu Wang, Beibei Wu, François‐Xavier Weill, Min Yue
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: EMBO Molecular Medicine, Vol 14, Iss 11, Pp 1-10 (2022)
Druh dokumentu: article
ISSN: 1757-4676
1757-4684
DOI: 10.15252/emmm.202216366
Popis: Abstract Invasive nontyphoidal Salmonella (iNTS) causes extraintestinal infections with ~15% case fatality in many countries. However, the mechanism by which iNTS emerged in China remains unaddressed. We conducted clinical investigations of iNTS infection with recurrent treatment failure, caused by underreported Salmonella enterica serovar Livingstone (SL). Genomic epidemiology demonstrated five clades in the SL population and suggested that the international animal feed trade was a likely vehicle for their introduction into China, as evidenced by multiple independent transmission incidents. Importantly, isolates from Clade‐5‐I‐a/b, predominant in China, showed an invasive nature in mice, chicken and zebrafish infection models. The antimicrobial susceptibility testing revealed most isolates (> 96%) in China are multidrug‐resistant (MDR). Overall, we offer exploiting genomics in uncovering international transmission led by the animal feed trade and highlight an emerging hypervirulent clade with increased resistance to frontline antibiotics.
Databáze: Directory of Open Access Journals
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