Upregulated Expression of a Unique Gene by Hepatitis B x Antigen Promotes Hepatocellular Growth and Tumorigenesis

Autor:	Zhaorui Lian, Jie Liu, Li Li, Xianxing Li, N. Lale Satiroglu Tutan, Marcy Clayton, Meng-Chao Wu, Hong-Yang Wang, Patrick Arbuthnot, Michael Kew, Mark A. Feitelson
Jazyk:	angličtina
Rok vydání:	2003
Předmět:	hepatitis B virus hepatitis B x antigen hepatocellular carcinoma oncogene cell cycle Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Neoplasia: An International Journal for Oncology Research, Vol 5, Iss 3, Pp 229-244 (2003)
Druh dokumentu:	article
ISSN:	1476-5586 1522-8002
DOI:	10.1016/S1476-5586(03)80055-6
Popis:	Hepatitis B x antigen (HBxAg) is a trans-activating protein that may be involved in hepatocarcinogenesis, although few natural effectors of HBxAg that participate in this process have been identified. To identify additional effectors, whole cell RNA isolated from HBxAg-positive and HBxAg-negative HepG2 cells were compared by polymerase chain reaction select cDNA subtraction, and one clone, upregulated gene, clone 11 (URG11), was chosen for further characterization. Elevated levels of URG11 mRNA and protein were observed in HBxAg-positive compared to HBxAg-negative HepG2 cells. Costaining was observed in infected liver (P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/a1bef10048614d7f96aaa8c7379c0aa5 Zobrazit plný text záznamu View record in DOAJ