Lymphocytopenia is associated with poor NYHA functional class in chronic heart failure patients with reduced ejection fraction

Autor: Hasan Yucel, Meltem Refiker Ege, Ali Zorlu, Hakki Kaya, Osman Beton, Hasan Gungor, Gurkan Acar, Ahmet Temizhan, Yüksel Çavuşoğlu, Mehdi Zoghi, Mehmet Eren, Dilek Ural, Mehmet Birhan Yilmaz
Jazyk: English<br />Turkish
Rok vydání: 2015
Předmět:
Zdroj: Türk Kardiyoloji Derneği Arşivi, Vol 43, Iss 5, Pp 427-433 (2015)
Druh dokumentu: article
ISSN: 1016-5169
DOI: 10.5543/tkda.2015.89439
Popis: OBJECTIVE: In heart failure (HF) patients, functional capacity has been demonstrated to be a marker of poor prognosis, independent of left ventricular ejection fraction (EF). Lymphocyte count is currently recognized in certain risk stratification scores for chronic HF, and severe HF is associated with lymphocytopenia. However, no data exists on the association between lymphocyte count and functional capacity in patients with stable HF. This study aimed to assess the relationship between lymphocyte count and New York Heart Association (NYHA) functional capacity in systolic HF outpatients. METHODS: The Turkish Research Team-HF (TREAT-HF) is a network which undertakes multi-center observational studies in HF. Data on 392 HF reduced ejection fraction (HFREF) patients from 8 HF centers are presented here. The patients were divided into two groups and compared: Group 1 comprised stable HFREF patients with mild symptoms (NYHA Class I-II), while Group 2 consisted of patients with NYHA Class III-IV symptoms. RESULTS: Patient mean age was 60+-14 years. Lymphocyte count was lower in patients with NYHA functional classes III and IV than in patients with NYHA functional classes I and II, (0.9 [0.6–1.5] x1000 versus 1.5 [0.7–2.2] x1000, p
Databáze: Directory of Open Access Journals