| Autor: |
Katrina S Pedersen, William R Bamlet, Ann L Oberg, Mariza de Andrade, Martha E Matsumoto, Hui Tang, Stephen N Thibodeau, Gloria M Petersen, Liang Wang |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 6, Iss 3, p e18223 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0018223 |
| Popis: |
Pancreatic adenocarcinoma (PaC) is one of most difficult tumors to treat. Much of this is attributed to the late diagnosis. To identify biomarkers for early detection, we examined DNA methylation differences in leukocyte DNA between PaC cases and controls in a two-phase study. In phase I, we measured methylation levels at 1,505 CpG sites in treatment-naïve leukocyte DNA from 132 never-smoker PaC patients and 60 never-smoker healthy controls. We found significant differences in 110 CpG sites (false discovery rate |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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