Novas estratégias terapêuticas para o tratamento da depressão: uma visão da química medicinal

Autor:	Romeiro Luiz Antonio Soares, Fraga Carlos Alberto Manssour, Barreiro Eliezer J.
Jazyk:	English<br />Spanish; Castilian<br />Portuguese
Rok vydání:	2003
Předmět:	monoamine oxidase inhibitors monoamine reuptake inhibitors serotonin receptor antagonists Chemistry QD1-999
Zdroj:	Química Nova, Vol 26, Iss 3, Pp 347-358 (2003)
Druh dokumentu:	article
ISSN:	0100-4042 1678-7064
Popis:	Depression is a widespread humor disturbance promoted mainly by depletion of biogenic neurotransmitter amines involved in the CNS synapses. Effective drug treatments for depression have been available for more than forty years. Despite its remarkable structural diversity, this paper discuss under the medicinal chemistry point of view, all different classes of "monoamine based" antidepressant drugs, emphasizing the rational design, structure-activity relationships (SAR), biotransformation and physico-chemical properties related with antidepressant activity and molecular mechanism of action.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/19b9505b0a8b43e5b25e8187a103bf98 Zobrazit plný text záznamu View record in DOAJ