Application of Cell-Derived Extracellular Vesicles and Engineered Nanovesicles for Hair Growth: From Mechanisms to Therapeutics

Autor: Prakash Gangadaran, Ramya Lakshmi Rajendran, Mi Hee Kwack, Madhan Jeyaraman, Chae Moon Hong, Young Kwan Sung, Byeong-Cheol Ahn
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Druh dokumentu: article
ISSN: 2296-634X
DOI: 10.3389/fcell.2022.963278
Popis: Hair loss is one of the most common disorders that affect both male and female patients. Cell-derived nanovesicles (CDVs) are natural extracellular vesicles and engineered nanovesicles that can carry various biologicals materials such as proteins, lipids, mRNA, miRNA, and DNA. These vesicles can communicate with local or distant cells and are capable of delivering endogenous materials and exogenous drugs for regenerative therapies. Recent studies revealed that CDVs can serve as new treatment strategies for hair growth. Herein, we review current knowledge on the role of CDVs in applications to hair growth. The in-depth understanding of the mechanisms by which CDVs enable therapeutic effects for hair growth may accelerate successful clinical translation of these vesicles for treating hair loss.
Databáze: Directory of Open Access Journals