Autor: |
William D. Stuart, Iris M. Fink-Baldauf, Koichi Tomoshige, Minzhe Guo, Yutaka Maeda |
Jazyk: |
angličtina |
Rok vydání: |
2021 |
Předmět: |
|
Zdroj: |
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021) |
Druh dokumentu: |
article |
ISSN: |
2399-3642 |
DOI: |
10.1038/s42003-021-02083-4 |
Popis: |
The transcription factor NKX2-1 is a key regulator of lung pathophysiology, but the importance of its binding sites outside of proximal promoter regions is unclear. Here, William Stuart and Iris Fink-Baldauf et al. use CRISPRi to interrogate 19 NKX2-1 binding sites and identify specific sites important for breathing, innate immune defense, and tumorigenesis. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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