Primary Nonfunction of Renal Allograft Secondary to Acute Oxalate Nephropathy

Autor: Ravi Parasuraman, Ping L. Zhang, Dilip Samarapungavan, Krishna Pothugunta, Gampala Reddy, Leslie Rocher, Francis Dumler, Vandad Raofi, Steven Cohn, Alan Koffron
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Case Reports in Transplantation, Vol 2011 (2011)
Druh dokumentu: article
ISSN: 2090-6943
2090-6951
DOI: 10.1155/2011/876906
Popis: Primary nonfunction (PNF) accounts for 0.6 to 8% of renal allograft failure, and the focus on causes of PNF has changed from rejection to other causes. Calcium oxalate (CaOx) deposition is common in early allograft biopsies, and it contributes in moderate intensity to higher incidence of acute tubular necrosis and poor graft survival. A-49-year old male with ESRD secondary to polycystic kidney disease underwent extended criteria donor kidney transplantation. Posttransplant, patient developed delayed graft function (DGF), and the biopsy showed moderately intense CaOx deposition that persisted on subsequent biopsies for 16 weeks, eventually resulting in PNF. The serum oxalate level was 3 times more than normal at 85 μmol/L (normal
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