| Autor: |
DD Marciniuk, P Hernandez, M Balter, J Bourbeau, KR Chapman, GT Ford, JL Lauzon, F Maltais, DE O’Donnell, D Goodridge, C Strange, AJ Cave, K Curren, S Muthuri, Canadian Thoracic Society COPD Clinical Assembly Alpha-1 Antitrypsin Deficiency Expert Working Group |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Canadian Respiratory Journal, Vol 19, Iss 2, Pp 109-116 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1198-2241 |
| DOI: |
10.1155/2012/920918 |
| Popis: |
Alpha-1 antitrypsin (A1AT) functions primarily to inhibit neutrophil elastase, and deficiency predisposes individuals to the development of chronic obstructive pulmonary disease (COPD). Severe A1AT deficiency occurs in one in 5000 to one in 5500 of the North American population. While the exact prevalence of A1AT deficiency in patients with diagnosed COPD is not known, results from small studies provide estimates of 1% to 5%. The present document updates a previous Canadian Thoracic Society position statement from 2001, and was initiated because of lack of consensus and understanding of appropriate patients suitable for targeted testing for A1AT deficiency, and for the use of A1AT augmentation therapy. Using revised guideline development methodology, the present clinical practice guideline document systematically reviews the published literature and provides an evidence-based update. The evidence supports the practice that targeted testing for A1AT deficiency be considered in individuals with COPD diagnosed before 65 years of age or with a smoking history of |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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