Case report of systemic sclerosis: Uncommon manifestation of nephrotic syndrome post-renal crisis
| Autor: | Ai Fujii, Takaya Kondo, Yasutaka Katsura, Sho Kumano, Serina Kita, Kazutoshi Nomura, Tomohisa Yabe, Norifumi Hayashi, Keiji Fujimoto, Hitoshi Yokoyama, Kengo Furuichi |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | SAGE Open Medical Case Reports, Vol 11 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2050-313X 2050313X |
| DOI: | 10.1177/2050313X231220801 |
| Popis: | Kidney involvement in systemic sclerosis occurs in about 20% of cases, with scleroderma renal crisis as a significant complication. However, cases of glomerular disease with massive proteinuria are rare. We present a unique case of systemic sclerosis with the development of nephrotic syndrome. The report provides clinical details and podocyte pathological findings. A 40-year-old male with prior skin sclerosis was diagnosed with systemic sclerosis. Treatment with oral prednisone led to gradual improvement, but a year later, he experienced a systemic sclerosis renal crisis. Using the angiotensin converting enzyme (ACE) inhibitors improved kidney function. However, 3 months later, nephrotic syndrome was diagnosed. Despite an increased prednisolone dose, proteinuria persisted. A kidney biopsy revealed glomerular sclerosis and characteristic vascular changes. Immunofluorescent studies showed no deposits. Electron microscopy confirmed podocyte abnormalities. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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