Platelet counts in HFE p.C282Y/p.C282Y and wt/wt post-screening clinical evaluation participants

Autor:	James C. Barton, J. Clayborn Barton, Ronald T. Acton
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	hemochromatosis serum ferritin transferrin saturation Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Platelets, Vol 34, Iss 1 (2023)
Druh dokumentu:	article
ISSN:	0953-7104 1369-1635 09537104
DOI:	10.1080/09537104.2023.2217933
Popis:	Our aim was to document the effects of genotype HFE p.C282Y/p.C282Y and hemochromatosis-associated laboratory and clinical manifestations on platelet counts (PC). We compiled genotype (p.C282Y/p.C282Y or HFE wt/wt (absence of p.C282Y and p.H63D (rs1799945)), age, sex, body mass index, presence/absence of chronic fatigue, swelling/tenderness of second/third metacarpophalangeal joints, and hyperpigmentation, transferrin saturation (TS), serum ferritin (SF), hemoglobin levels, absolute neutrophil, lymphocyte, and monocyte counts, C-reactive protein levels, and PC of non-Hispanic white participants in a hemochromatosis and iron overload post-screening clinical examination. There were 171 men and 254 women (141 p.C282Y/p.C282Y, 284 wt/wt) of median age 53 y. Median TS and SF were higher in p.C282Y/p.C282Y than wt/wt participants grouped by sex (p
Databáze:	Directory of Open Access Journals
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