Retroviral Infection and Commensal Bacteria Dependently Alter the Metabolomic Profile in a Sterile Organ

Autor:	Jessica Spring, Vera Beilinson, Brian C. DeFelice, Juan M. Sanchez, Michael Fischbach, Alexander Chervonsky, Tatyana Golovkina
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	retroviruses microbiota commensal bacteria metabolites Microbiology QR1-502
Zdroj:	Viruses, Vol 15, Iss 2, p 386 (2023)
Druh dokumentu:	article
ISSN:	1999-4915
DOI:	10.3390/v15020386
Popis:	Both viruses and bacteria produce “pathogen associated molecular patterns” that may affect microbial pathogenesis and anti-microbial responses. Additionally, bacteria produce metabolites, while viruses could change the metabolic profiles of the infected cells. Here, we used an unbiased metabolomics approach to profile metabolites in spleens and blood of murine leukemia virus-infected mice monocolonized with Lactobacillus murinus to show that viral infection significantly changes the metabolite profile of monocolonized mice. We hypothesize that these changes could contribute to viral pathogenesis or to the host response against the virus and thus open a new avenue for future investigations.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/de175d4fd6454ba1aa7d7dbbf05ea48d Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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