An Efficient and Eco-Friendly Procedure for Electrophilic Thiocyanation of Anilines and 1-(Substituted benzylidene)-2-phenyl Hydrazines

Autor:	A. M. M. Mallikarjunaswamy, Gouthami Kuruvalli, Khajamohiddin Syed, Vaddi Damodara Reddy, Vipin A. Nair
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	N-bromosuccinimide KSCN aromatic amines schiff bases electrophilic thiocyanation Chemistry QD1-999
Zdroj:	Chemistry, Vol 6, Iss 3, Pp 476-488 (2024)
Druh dokumentu:	article
ISSN:	2624-8549
DOI:	10.3390/chemistry6030027
Popis:	Thiocyanates form an important class of organic compounds commonly found in natural products that exhibit excellent antimicrobial activity. The electrophilic thiocyanation is one of the most effective methods of introducing a -SCN functional group to the parent organic molecule. In this work, we explored an eco-friendly and highly efficient method for thiocyanation of anilines and 1-(substituted benzylidene)-2-phenylhydrazines using commercially available N-bromoscuccinimide (NBS) and potassium thiocyanate (KSCN). The optimized protocol afforded thiocyanates with good regioselectivity and excellent yields in comparison to the available methods.
Databáze:	Directory of Open Access Journals
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