The role of coagulation and inflammation in the development of diabetic nephropathy in patients withdiabetes mellitus type 2

Autor:	Yulia Valer'evna Khasanova, Alsu Asatovna Nelaeva, Anna Borisovna Galkina, Irina Vasil'evna Medvedeva
Jazyk:	English<br />Russian
Rok vydání:	2012
Předmět:	diabetes mellitus type 2 diabetic nephropathy chronic kidney disease coagulopathy iterleikin-6 homocystein inflammation Nutritional diseases. Deficiency diseases RC620-627
Zdroj:	Сахарный диабет, Vol 15, Iss 1, Pp 31-34 (2012)
Druh dokumentu:	article
ISSN:	2072-0351 2072-0378
DOI:	10.14341/2072-0351-5976
Popis:	Aim. To reveal the role of inflammatory markers (homocystein (HC), interleukin-6 (IL-6)), components of hemostatic mechanism ofcoagulation in the development of diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM). Materials and methods. A total of 240 patients with T2DM and DN were examined. Results. Negative correlation between HC level and glomerular filtration rate (GFR) (r= -0,38) and positive correlation between IL-6and fibrinogen (r=0,55) were observed. Conclusion. Inflammation and changes in mechanism of coagulation have influence on development and progression of DN in patientswith T2DM.
Databáze:	Directory of Open Access Journals
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