Clinical research of perioperative serum VEGF and MMP-9 levels in patients with non-small cell lung cancer
| Autor: | Ying HU, Baolan LI, Changxing SONG |
|---|---|
| Jazyk: | čínština |
| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Chinese Journal of Lung Cancer, Vol 11, Iss 5, Pp 734-738 (2008) |
| Druh dokumentu: | article |
| ISSN: | 1009-3419 1999-6187 |
| Popis: | Background and objective Angiogenesis is necessary in tumor progression and metastasis. Serumvascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) are important factors in angiogenesis.Elevated levels of VEGF and MMP-9 were reported in lung cancer. The aim of this research is to study the dynamic changes of serum VEGF and MMP-9 levels in non-small cell lung cancer (NSCLC) patients who underwent surgery. Methods Serum VEGF and MMP-9 levels were determined in 57 patients with NSCLC who were undergoing surgery byELISA (enzyme linked immunosorbent assay) method before operation and on postoperative day 1, 7, 14. At the same time18 patients with pulmonary benign diseases treated by surgery were studied as the control. Thirty healthy volunteers servedto define normal VEGF and MMP-9. Results Preoperative serum VEGF levels (685.50 pg/mL) was significantly higherin the group of patients with NSCLC compared with the benign and healthy group (respectively: 160.90 pg/mL, 94.40 pg/mL) (P |
| Databáze: | Directory of Open Access Journals |
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