Microenvironment of spermatogonial stem cells: a key factor in the regulation of spermatogenesis

Autor:	Wei Liu, Li Du, Junjun Li, Yan He, Mengjie Tang
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Spermatogonial stem cells Microenvironment Niche Self-renewal Differentiation Spermatogenesis Medicine (General) R5-920 Biochemistry QD415-436
Zdroj:	Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-22 (2024)
Druh dokumentu:	article
ISSN:	1757-6512
DOI:	10.1186/s13287-024-03893-z
Popis:	Abstract Spermatogonial stem cells (SSCs) play a crucial role in the male reproductive system, responsible for maintaining continuous spermatogenesis. The microenvironment or niche of SSCs is a key factor in regulating their self-renewal, differentiation and spermatogenesis. This microenvironment consists of multiple cell types, extracellular matrix, growth factors, hormones and other molecular signals that interact to form a complex regulatory network. This review aims to provide an overview of the main components of the SSCs microenvironment, explore how they regulate the fate decisions of SSCs, and discuss the potential impact of microenvironmental abnormalities on male reproductive health. Graphical Abstract
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/1613ce00bcc742f6af02a9fe0650a208 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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