| Autor: |
Jihad M. Al-Ajlouni, MD, FRCS, Mohammed S. Alisi, MD, Mohamad S. Yasin, MD, Aws Khanfar, MD, Mohammad Hamdan, MD, Ahmad Abu Halaweh, MD, Hashem Al Hawamdeh, MD, Khamis Elessi, MSc-EBM, Mohammad S. Alsbou, MD, PhD |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Arthroplasty Today, Vol 6, Iss 4, Pp 689-693 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2352-3441 |
| DOI: |
10.1016/j.artd.2020.07.037 |
| Popis: |
Alkaptonuria is a rare autosomal recessive metabolic disorder. It is characterized by the accumulation of homogentisic acid in the body due to a lack of enzymes that degrade it. Over time, it results in joint degeneration and eventually leads to ochronosis. Ochronosis refers to bluish-black discoloration of connective and other tissues within the body. In this study, we present 5 distinct cases diagnosed with alkaptonuria. They have undergone 8 total joint replacement surgeries (4 hips and 4 knees) within 8 years (2010-2018). All patients had an excellent outcome over several years. The follow-up period ranged from 2 to 10 years. Although none of the presented cases had intraoperative or postoperative adverse sequelae, we must take care when dealing with patients with ochronotic arthropathy. They carry a higher risk of complications than other patients with osteoarthritis disease. These complications include fractures due to fragile bone quality, muscle or tendon rupture, joint instability, and anesthesia-related complications. Total joint arthroplasty is a valid and safe option in the management of hip and knee ochronotic arthropathy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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