Decreasing Non–bladder-cancer Mortality After Radical Cystectomy

Autor: Michael Froehner, Rainer Koch, Ulrike Heberling, Angelika Borkowetz, Matthias Hübler, Vladimir Novotny, Manfred P. Wirth, Christian Thomas
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: European Urology Open Science, Vol 29, Iss , Pp 15-18 (2021)
Druh dokumentu: article
ISSN: 2666-1683
DOI: 10.1016/j.euros.2021.04.007
Popis: Life expectancy is increasing in many parts of the world. Using proportional hazard models for competing risks, we investigated whether this increase has changed outcomes after radical cystectomy in a sample of 1419 consecutive patients treated between 1993 and 2018. During the observation period, the mean age and the proportion of patients with American Society of Anesthesiologists physical status class 3 or 4 increased, whereas the proportion of patients with heart disease decreased. Competing mortality (causes other than bladder cancer) decreased in all subgroups (hazard ratios [HRs] per year ranged from 0.931 to 0.963) and after controlling for increasing age (HRs ranged from 1.018 to 1.081). In an optimal model resulting from an analysis including age (HR per year 1.048, 95% confidence interval [CI] 1.027–1.070; p
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