Increased risk factors associated with lower BMD in antiretroviral-therapy–naïve HIV-infected adult male

Autor: Patricia Atencio, Alfonso Cabello, Francisco M. Conesa-Buendía, Ramón Pérez-Tanoira, Laura Prieto-Pérez, Irene Carrillo, Beatriz Álvarez, Rosa Arboiro-Pinel, Manuel Díaz-Curiel, Gabriel Herrero-Beaumont, Aránzazu Mediero, Miguel Górgolas
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-8 (2021)
Druh dokumentu: article
ISSN: 1471-2334
DOI: 10.1186/s12879-021-06263-9
Popis: Abstract Background Low BMD (bone mineral density) has been described as a non–AIDS (Acquired Immune Deficiency Syndrome)-related event in HIV (human immunodeficiency virus)-patients but it is poorly studied in young HIV-infected men who have received no previous antiretroviral therapy. Methods A cross-sectional study of 245 naïve-HIV-infected men over 21 and under 50 years old who voluntary attended the Infectious Disease Division appointment in Hospital Fundación Jimenez Díaz in Madrid, from January 1st, 2014 to September 30th, 2017. All subjects underwent a baseline DXA scan (dual energy x-ray absorptiometry) performed prior to start antiretroviral treatment. Further, all patients who started treatment between May 1st and September 30th, 2017 were invited to participate in a substudy on bone mineral metabolism. All the information was collected through clinical history and complementary questionnaire. Results The mean age was 36.4 years, been 68% Caucasian, 29.3% Latin American and 2.7% African race. At the time of diagnosis, 91% of patients had stage-A (median CD4+ T-cell 481cells/μL, IQR, 320–659). 10% had a count below 200 CD4 cells/μL, and 40% had a CD4/CD8 cell-count-ratio below 0.4. Regarding lifestyle and risk factors, 14.1% presented underweight, 36.1% were not engage in any regular exercise, 51.9% were active smokers and 35.3% reported drug use. Low levels of vitamin D were seen in 87.6% of the study participants. Low BMD (Z-score
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