Deciphering the quality of SARS‐CoV‐2 specific T‐cell response associated with disease severity, immune memory and heterologous response

Autor: Alberto Pérez‐Gómez, Carmen Gasca‐Capote, Joana Vitallé, Francisco J. Ostos, Ana Serna‐Gallego, María Trujillo‐Rodríguez, Esperanza Muñoz‐Muela, Teresa Giráldez‐Pérez, Julia Praena‐Segovia, María D. Navarro‐Amuedo, María Paniagua‐García, Manuel García‐Gutiérrez, Manuela Aguilar‐Guisado, Inmaculada Rivas‐Jeremías, María Reyes Jiménez‐León, Sara Bachiller, Alberto Fernández‐Villar, Alexandre Pérez‐González, Alicia Gutiérrez‐Valencia, Mohammed Rafii‐El‐Idrissi Benhnia, Daniela Weiskopf, Alessandro Sette, Luis F. López‐Cortés, Eva Poveda, Ezequiel Ruiz‐Mateos, Virgen del Rocío Hospital COVID‐19 and COHVID‐GS Working Teams
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Clinical and Translational Medicine, Vol 12, Iss 4, Pp n/a-n/a (2022)
Druh dokumentu: article
ISSN: 2001-1326
DOI: 10.1002/ctm2.802
Popis: Abstract SARS‐CoV‐2 specific T‐cell response has been associated with disease severity, immune memory and heterologous response to endemic coronaviruses. However, an integrative approach combining a comprehensive analysis of the quality of SARS‐CoV‐2 specific T‐cell response with antibody levels in these three scenarios is needed. In the present study, we found that, in acute infection, while mild disease was associated with high T‐cell polyfunctionality biased to IL‐2 production and inversely correlated with anti‐S IgG levels, combinations only including IFN‐γ with the absence of perforin production predominated in severe disease. Seven months after infection, both non‐hospitalised and previously hospitalised patients presented robust anti‐S IgG levels and SARS‐CoV‐2 specific T‐cell response. In addition, only previously hospitalised patients showed a T‐cell exhaustion profile. Finally, combinations including IL‐2 in response to S protein of endemic coronaviruses were the ones associated with SARS‐CoV‐2 S‐specific T‐cell response in pre‐COVID‐19 healthy donors’ samples. These results could have implications for protective immunity against SARS‐CoV‐2 and recurrent COVID‐19 and may help for the design of new prototypes and boosting vaccine strategies.
Databáze: Directory of Open Access Journals
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