Different prevalence of T2DM risk alleles in Roma population in comparison with the majority Czech population

Autor:	Jaroslav A. Hubáček, Lenka Šedová, Věra Olišarová, Věra Adámková, Valérie Tóthová
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Czech population gene score polymorphism Roma population T2DM Genetics QH426-470
Zdroj:	Molecular Genetics & Genomic Medicine, Vol 8, Iss 9, Pp n/a-n/a (2020)
Druh dokumentu:	article
ISSN:	2324-9269
DOI:	10.1002/mgg3.1361
Popis:	Abstract Background The Czech governmental study suggests up to a 25% higher prevalence of type 2 diabetes mellitus (T2DM) in the Roma population than within the majority population. It is not known whether and to what extent these differences have a genetic background. Methods To analyze whether the frequencies of the alleles/genotypes of the FTO, TCF7L2, CDKN2A/2B, MAEA, TLE4, IGF2BP2, ARAP1, and KCNJ11 genes differ between the two major ethnic groups in the Czech Republic, we examined them in DNA samples from 302 Roma individuals and 298 Czech individuals. Results Compared to the majority population, Roma are more likely to carry risk alleles in the FTO (26% vs. 16% GG homozygotes, p
Databáze:	Directory of Open Access Journals
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