Pathogenesis, evaluation and pathogenetic therapy of diabetic polyneuropathy

Autor:	I. A. Strokov, V. V. Oganov
Jazyk:	ruština
Rok vydání:	2021
Předmět:	diabetes mellitus diabetic polyneuropathy evaluation pathogenetic therapy alpha-lipoic acid symptom-modifying treatment disease-modifying treatment Neurology. Diseases of the nervous system RC346-429
Zdroj:	Неврология, нейропсихиатрия, психосоматика, Vol 13, Iss 3, Pp 99-106 (2021)
Druh dokumentu:	article
ISSN:	2074-2711 2310-1342
DOI:	10.14412/2074-2711-2021-3-99-106
Popis:	The increase in the number and life expectancy of patients with diabetes mellitus (DM) worldwide determines the high prevalence of late complications of diabetes, including diabetic polyneuropathy (DPN), the most common type of polyneuropathy. Oxidative stress is considered the main reason for the cellular pathology development in diabetes mellitus, which determines the use of antioxidants for the DPN treatment. Alpha-lipoic acid (ALA), a natural fat-soluble antioxidant, is the most effective drug for reducing DPN symptoms. Furthermore, the symptom-modifying effect of ALA has been shown in numerous randomized controlled trials. The article discusses the possible disease-modifying effect of ALA.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/145410050b194ea6ab3b7d37178d08cb Zobrazit plný text záznamu View record in DOAJ