Benefits of Autoantibody Enrichment in Early Rheumatoid Arthritis: Analysis of Efficacy Outcomes in Four Pooled Abatacept Trials

Autor:	Kaleb Michaud, Philip G. Conaghan, Sang Hee Park, Karissa Lozenski, Mirko Fillbrunn, Vadim Khaychuk, Elyse Swallow, John Vaile, Henry Lane, Ha Nguyen, Janet Pope
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Abatacept Anti-citrullinated protein antibody Cross-trial analysis Rheumatoid arthritis Rheumatoid factor Seropositive Diseases of the musculoskeletal system RC925-935
Zdroj:	Rheumatology and Therapy, Vol 10, Iss 4, Pp 951-967 (2023)
Druh dokumentu:	article
ISSN:	2198-6576 2198-6584
DOI:	10.1007/s40744-023-00552-2
Popis:	Abstract Introduction The efficacy of abatacept is enhanced in anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF)-positive versus -negative patients with rheumatoid arthritis (RA). Four early RA abatacept trials were analyzed to understand the differential impact of abatacept among patients with SeroPositive Early and Active RA (SPEAR) compared to non-SPEAR patients. Methods Pooled patient-level data from AGREE, AMPLE, AVERT, and AVERT-2 were analyzed. Patients were classified as SPEAR if they were ACPA +, RF +, disease duration
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/137cbb57a6ff4745a740f7aecc9c629e Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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