Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis

Autor:	Samantha Paterson, Antoine Vallatos, Jean Rodgers, William M. Holmes
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Medicine Science
Zdroj:	Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-023-34665-z
Popis:	Abstract Human African Trypanosomiasis (HAT) is a parasitic disease originating in sub-Saharan Africa. There is limited information about the changes in the blood brain barrier (BBB) during this infection. This study is the first to apply diffusion weighted ASL (DWASL) to examine changes in BBB impairment. No significant changes in water exchange across the BBB were found during the infection, even when a loss of barrier integrity was seen using Contrast Enhanced MRI (Gd-DTPA) during the late stage of the disease. Furthermore, using multiple boli ASL (mbASL), changes in cerebral blood flow (CBF) were found during the course of infection. Overall, this study highlights the need for further study of the BBB during HAT infection to understand the complex mechanisms behind impairment.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/13719810abe64c25913e1c6cb32c55a8 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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