Gut microbiota and immunotherapy of renal cell carcinoma

Autor:	Stefano Bibbò, Serena Porcari, Livio Enrico Del Vecchio, Andrea Severino, Benjamin H. Mullish, Gianluca Ianiro, Antonio Gasbarrini, Giovanni Cammarota
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Microbiota immunotherapy immune checkpoint inhibitors oncology probiotic prebiotic Immunologic diseases. Allergy RC581-607 Therapeutics. Pharmacology RM1-950
Zdroj:	Human Vaccines & Immunotherapeutics, Vol 19, Iss 3 (2023)
Druh dokumentu:	article
ISSN:	21645515 2164-554X 2164-5515
DOI:	10.1080/21645515.2023.2268982
Popis:	ABSTRACTThe gut microbiome has recently been proposed as a key player in cancer development and progression. Several studies have reported that the composition of the gut microbiome plays a role in the response to immune checkpoint inhibitors (ICIs). The gut microbiome modulation has been investigated as a potential therapeutic strategy for cancer, mainly in patients undergoing therapy with ICIs. In particular, modulation through probiotics, FMT or other microbiome-related approaches have proven effective to improve the response to ICIs. In this review, we examine the role of the gut microbiome in enhancing clinical responses to ICIs in the treatment of renal cancer.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/13404a7dca4649dc92e9618225294e18 Zobrazit plný text záznamu View record in DOAJ