Host intestinal biomarker identification in a gut leakage model in broilers

Autor: Fien De Meyer, Venessa Eeckhaut, Richard Ducatelle, Maarten Dhaenens, Simon Daled, Annelike Dedeurwaerder, Maarten De Gussem, Freddy Haesebrouck, Dieter Deforce, Filip Van Immerseel
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Veterinary Research, Vol 50, Iss 1, Pp 1-14 (2019)
Druh dokumentu: article
ISSN: 1297-9716
DOI: 10.1186/s13567-019-0663-x
Popis: Abstract Intestinal health problems are a major issue in the poultry industry. Quantifiable easy-to-measure biomarkers for intestinal health would be of great value to monitor subclinical intestinal entities that cause performance problems and to evaluate control methods for intestinal health. The aim of the study was to identify host protein biomarkers for intestinal inflammation and intestinal barrier damage. Proteomic analysis was conducted on ileal and colonic content samples of broilers under an experimental gut damage and inflammation model. Effects of the challenge treatment resulted in a worse gut condition based on macroscopic gut appearance (p
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