A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain.

Autor:	Stephen Muhi, Joshua Osowicki, Daniel O'Brien, Paul D R Johnson, Sacha Pidot, Marcel Doerflinger, Julia L Marshall, Marc Pellegrini, James McCarthy, Timothy P Stinear
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Zdroj:	PLoS Neglected Tropical Diseases, Vol 17, Iss 6, p e0011394 (2023)
Druh dokumentu:	article
ISSN:	1935-2727 1935-2735
DOI:	10.1371/journal.pntd.0011394
Popis:	Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines for prevention of this neglected tropical disease. Here, we review the current understanding of host-pathogen interactions and correlates of immune protection to explore the case for establishing a controlled human infection model of M. ulcerans infection. We also summarise the overarching safety considerations and present a rationale for selecting a suitable challenge strain.
Databáze:	Directory of Open Access Journals
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