| Autor: |
Husna Dharma Putera, Rumi Iqbal Doewes, Mohammed Nader Shalaby, Andrés Alexis Ramírez-Coronel, Zachary S. Clayton, Walid Kamal Abdelbasset, Saidmurodkhon S. Murtazaev, Abduladheem Turki Jalil, Pegah Rahimi, Elyas Nattagh-Eshtivani, Mahsa Malekahmadi, Naseh Pahlavani |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Nutrition & Metabolism, Vol 20, Iss 1, Pp 1-16 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1743-7075 |
| DOI: |
10.1186/s12986-023-00758-9 |
| Popis: |
Abstract Conjugated linoleic acids (CLAs) are polyunsaturated fatty acids primarily found in dairy products and ruminant animal products such as beef, lamb, and butter. Supplementation of CLAs has recently become popular among athletes due to the variety of health-promoting effects, including improvements in physical performance. Preclinical and some clinical studies have shown that CLAs can reduce inflammation and oxidative stress and favorably modulate body composition and physical performance; however, the results of previously published clinical trials are mixed. Here, we performed a comprehensive review of previously published clinical trials that assessed the role of CLAs in modulating inflammation, oxidative stress, body composition, and select indices of physical performance, emphasizing the molecular mechanisms governing these changes. The findings of our review demonstrate that the effect of supplementation with CLAs on inflammation and oxidative stress is controversial, but this supplement can decrease body fat mass and increase physical performance. Future well-designed randomized clinical trials are warranted to determine the effectiveness of (1) specific doses of CLAs; (2) different dosing durations of CLAs; (3) various CLA isomers, and the exact molecular mechanisms by which CLAs positively influence oxidative stress, inflammation, body composition, and physical performance. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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