| Autor: |
Céline Row, Nicolas Lechevalier, Jean Philippe Vial, Aguirre Mimoun, Jean Noel Bastie, Ingrid Lafon, Arnaud Pigneux, Thibaut Leguay, Mary Callanan, Marc Maynadie, Marie C. Béné, Pierre Yves Dumas, Julien Guy |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
eJHaem, Vol 5, Iss 1, Pp 84-92 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2688-6146 |
| DOI: |
10.1002/jha2.822 |
| Popis: |
Abstract Risk stratification and treatment response evaluation are key features in acute myeloid leukemia (AML) management. Immunophenotypic and molecular approaches all rely on the detection of persisting leukemic cells by measurable residual disease techniques. A new approach is proposed here by assessing medullary myeloid maturation by flow cytometry through a myeloid progenitor ratio (MPR). The normal MPR range was defined using reference normal bone marrows (n = 48). MPR was considered balanced if between 1 and 4 and unbalanced if 4. MPR was retrospectively assessed at baseline and post‐induction for 206 newly diagnosed AML patients eligible for intensive treatment from two different French centers. All AML baseline MPR were unbalanced and thus significantly different from normal MPR (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Plný text