| Autor: |
Faruque Ahmed, Pallavi Anand, P. Satanarayana, Sapna Singh, Anil Kumar |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Al Ameen Journal of Medical Sciences, Vol 13, Iss 04, Pp 248-254 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
0974-1143 |
| Popis: |
Background: In the present study Xbal gene polymorphism was exposed with the use of PCR and its co-relation was established with the level of vitamin D in the pre-menopausal and post-menopausal women of north Indian population. There are several pre and post-menopausal women in this region are suffering from vitamin D deficiency. Objective: The main objective of this research was to find out Xbal gene polymorphism and % of its genotypes in respect to vitamin D in the pre-menopausal and post-menopausal women of north Indian population. This is a novel study of Xbal gene polymorphisms in the north Indian women. Methods: Patients suffered with vitamin D deficiency was calculated as protocol proposed by WHO and calculated total cholesterol level, BMI etc. For Xbal gene variation DNA was isolated with Qaigen kit and isolated DNA was amplified with PCR. Amplified DNA was separated with 1% agarose gel electrophoresis. The Hardy-Weinberg equilibrium, OR, CI and P-value were estimated using standard protocols. Results: Xbal gene polymorphism was found co-related significantly with vitamin D deficiency in the pre-menopausal and post-menopausal women. The GG genotype frequency was found three fold more prone for vitamin deficiency with (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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