| Autor: |
Ayhan Tanyeli, Derya Güzel, Songül Doğanay, Mustafa Can Güler, Ersen Eraslan |
| Jazyk: |
English<br />Turkish |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Sakarya Tıp Dergisi, Vol 11, Iss 1, Pp 142-147 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2146-409X |
| DOI: |
10.31832/smj.787082 |
| Popis: |
Objective: Here, possible protective effects of Urapidil were investigated against lung and renal injuries induced by cecal ligation and puncture (CLP). Materials and Methods: 32 Sprague Dawley male rats were assigned to 4 groups as follows; sham, CLP, DMSO and Urapidil (URA) 0.5 mg/kg. Several oxidant, inflammatory and antioxidant parameters were determined in lung and renal tissues. Results: Oxidant and inflammatory biomarkers increased while antioxidant biomarkers decreased in CLP and DMSO groups compared to sham group. Antioxidant parameters increased while oxidant and inflammatory biomarkers declined in treatment group compared to CLP and DMSO groups. Conclusion: Present results have demonstrated that URA administration is effective against lung and renal injuries caused by CLP-related polymicrobial sepsis model. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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