Plasminogen activator inhibitor-1 (PAI-1) and urokinase plasminogen activator (uPA) in sputum of allergic asthma patients.
| Autor: | Sebastian Zukowski, Krzysztof Kowal, Marcin Moniuszko, Anna Bodzenta-Łukaszyk |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Folia Histochemica et Cytobiologica, Vol 46, Iss 2, Pp 193-198 (2008) |
| Druh dokumentu: | article |
| ISSN: | 0239-8508 1897-5631 |
| DOI: | 10.5603/4443 |
| Popis: | Urokinase plasminogen activator (uPA) and its inhibitor (PAI-1) have been associated with asthma. The aim of this study was to evaluate concentration of uPA and PAI-1 in induced sputum of house dust mite allergic asthmatics (HDM-AAs). The study was performed on 19 HDM-AAs and 8 healthy nonatopic controls (HCs). Concentration of uPA and PAI-1 was evaluated in induced sputum supernatants using ELISA method. In HDM-AAs the median sputum concentration of uPA (128 pg/ml; 95% CI 99 to 183 pg/ml) and PAI-1 (4063 pg/ml; 95%CI 3319 to 4784 pg/ml) were significantly greater than in HCs (17 pg/ml; 95%CI 12 to 32 pg/ml; p |
| Databáze: | Directory of Open Access Journals |
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