| Autor: |
Nathalia Mayumi Noda-Nicolau, Mariana de Castro Silva, Giovana Fernanda Cosi Bento, Jeniffer Sena Baptista Ferreira, Juliano Novak, Júlia Andrade Pessoa Morales, Júlia Abbade Tronco, Aline Nascimento Bolpetti, Gabriel Vitor Silva Pinto, Jossimara Polettini, Camila Marconi, Márcia Guimarães da Silva |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 16, Iss 12, p e0260753 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0260753 |
| Popis: |
AimsTo compare the cervicovaginal levels of human beta defensin (hBD)-1, 2 and 3 of women according to the status of Nugent-defined bacterial vaginosis (BV).MethodsA total of 634 women of reproductive age were included in the study. Participants were equally distributed in two groups: according to the classification of vaginal smears according to Nugent criteria in normal (scores 0 to 3) and BV (scores ≥7). Cervicovaginal fluid samples were used for measurements of hBDs1, 2 and 3 levels by enzyme-linked immunosorbent assay (ELISA). Levels of each hBD were compared between the two study groups using Mann-Whitney test, with p-value ResultsCervicovaginal fluids from women with BV showed lower levels of hBD-1 [median 2,400.00 pg/mL (0-27,800.00); pConclusionsBacterial vaginosis is associated with lower cervicovaginal levels of hBDs1-3 in reproductive-aged women. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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