| Autor: |
Ana Paula Carvalho Reis, Franciele Fernandes Correia, Thais Martins Jesus, Carla Pagliari, Neusa Y Sakai-Valente, Walter Belda Júnior, Paulo Ricardo Criado, Gil Benard, Maria Gloria Teixeira Sousa |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 61 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1678-9946 |
| DOI: |
10.1590/s1678-9946201961056 |
| Popis: |
ABSTRACT Dermatophytosis is a cutaneous mycosis caused by a plethora of keratinophilic fungi, but Trichophyton rubrum is the most common etiological agent. Despite its high prevalence worldwide, little is known about the host defense mechanisms in this infection, particularly the in situ immune response. Using an immunohistochemistry approach, we investigated the density of CD1a+, factor XIIIa+ and CD68+ cells in the skin of dermatophytosis patients. Langerhans cells (CD1a+ cells) were significantly decreased in the epidermis of patients, both in affected and unaffected areas. In the dermis, however, no differences in the density of macrophages (CD68+ cells) and dermal dendrocytes (factor XIIIa+ cells) were observed. These results suggest that the decreased number of Langerhans cells may be a risk factor for development of dermatophytosis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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