Seasons can influence the results of the methacholine challenge test
| Autor: | Bruno Sposato, Marco Scalese, Andrea Pammolli, Raffaele Scala, Mario Naldi |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Annals of Thoracic Medicine, Vol 7, Iss 2, Pp 61-68 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1817-1737 1998-3557 |
| DOI: | 10.4103/1817-1737.94521 |
| Popis: | Objective: This study tried to evaluate whether a methacholine test may be influenced by the seasons. Methods: We considered 4826 consecutive subjects with normal spirometry (50.53% males; age: 35.1±16.2; forced expiratory volume in one second: 99.5±13.0%) who underwent a methacholine test for suspected asthma symptoms between 2000 and 2010. They were subdivided into four groups, like the seasons, according to the test dates. Results: A total of 1981 (41%) resulted normal (no PD 20 was obtained with 2400 μg of methacholine); the others showed a mean LogPD 20 of 2.52±0.5 μg. The number of subjects with bronchial hyper-responsiveness (BHR) found in autumn (789, 62.3%) was higher than in summer (583, 56.7%; P=0.03). A higher number of females and overweight/obese subjects showed a BHR in autumn compared with the other seasons. The spring mean LogPD 20 value (2.48±0.48 μg) was lower if compared with the one measured in summer (2.59±0.49 μg; P=0.05). LogPD 20 value was lower in females and non-smokers in spring compared with summer (P |
| Databáze: | Directory of Open Access Journals |
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